"SAFE HARBOR" STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995 Statements integrated herein that be not historical facts are forwarding-looking affidavit. Such forward-looking statements emergency a cipher of risk and uncertainties and are premise to move at any instance. In the occasion such risks or uncertainties materialize, Shire plc's grades could be materially overformal. The risks and uncertainties encompass, but are not controlled to: risks associated beside the ingrained ambiguity of pharmaceutical research, article of trade fruition, work and commercialization; the impact of aggressive products, mutually with, but not limited to, the impact of those with the tenderloin of Shire plc's Attention Deficit and Hyperactivity Disorder ("ADHD") franchise; exclusive rights, including but not limited to, endorsed provoke relating to Shire plc's ADHD franchise; establishment deference and commendation, including but not limited to the anticipated product approval date of SPD503 (ADHD), SPD465 (ADHD), MESAVANCE (SPD476) (ulcerative colitis), ELAPRASE (I2S) (Hunter syndrome) and NRP104 (ADHD), including its scheduling organization by the Drug Enforcement Administration surrounded by the United States; Shire plc's facility to outward ease from the purchase of Transkaryotic Therapies Inc.; Shire plc's ability to secured alien products all for commercialization and/or development; and other risks and uncertainties detailed on occasion in Shire plc's and its predecessor registrant Shire Pharmaceuticals Group plc's filings with the US Securities and Exchange Commission, including Shire plc's Annual Report on Form 10-K for the year complete December 31, 2005.
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