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DURECT Forward Looking Statement The statement here constrict unlock concerning ELADUR, its anticipated attributes and commercial soon-to-be, its potential to be a best in class transdermal product for those suffering from PHN and its potential to receive seven years of pageant exclusivity as an orphan drug are forward-looking statements involving chance and uncertainties that can ship actual results to contrast materially from those in such forward-looking statements. Potential risks and uncertainties involve, but are not limited to, the risk that ELADUR may not be the furthermost rough and primed bupivacaine product approved for PHN, DURECT's gift to logo, enroll, conduct and entire clinical trial, complete the design, development, and business way development of ELADUR, pick up product and manufacturing approvals from regulatory agencies and convention and commercialize ELADUR, and as marketplace acquiescence of the product candidate. Further information regarding these and other risks is integrated in DURECT's Form 10-Q dated May 8, 2008 under the heading "Risk Factors." DURECT Corporation
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The supreme demonstrated method of bariatric surgery be laparoscopic gastric bypass and laparoscopic adjustable gastric banding (LAGB). In gastric bypass, the belly be reduced from the vastness of a football to the size of a golf globe and feed is made to bypass fragment of the undersized intestine. In LAGB, a silicone leash is wrap going on for the upper part of the stomach to confine the amount of food the stomach can total. The amount of check is on the same wavelength by channel of tallying or removing saline from the band.
Two considerable barb become skilled at, published within the New England Journal of Medicine in August 2007, transmission patients to hand morbid stoutness who hold bariatric surgery (including gastric banding, gastric bypass, and vertical banded gastroplasty) gone astray famous mass complete the long-term and are to a great extent smaller amount eventual to give aloft the spectre from heart illness, diabetes and cancer seven to 10 years behind the mission than those who fulfil not have surgery [1], [2]. A 2004 study in the Journal of the American Medical Association showed that bariatric surgery resolved or better genus 2 diabetes in 86 percent of patients and resolved nod bad apnea in greater than 85 percent of patients [3].
The Agency in support of Healthcare Research and Quality (AHRQ) lately report that bariatric surgery is safer than ever. The speculate of demise from bariatric surgery have decline from 0.89 percent in 1998, to 0.19 percent in 2004. [4] About 64 million or 32 percent of adults in the U.S. are considered obese, which is associated with copious other disease and stipulations together with type 2 diabetes, heart disease, sleep apnea, hypertension, asthma, cancer, combined systematic hitches and unproductiveness. The pilot and obscure costs to the Healthcare policy associated with obesity are about $117 billion annually.
The ASMBS is the largest procedure for bariatric surgeons in the world. It is a non-profit organization that works to respect the art and science of bariatric surgery and is committed to educating medical professionals and the lay laypeople about bariatric surgery by means of an leeway for the psychoanalysis of morbid obesity, correspondingly as the associated risk and benefits. It buoy its accomplice to scrutinize and stumble on bright advance in bariatric surgery, while persist a the same as trade of go through and thinking that may front to improved surgical develop for morbidly obese patients. For more wits by the ASMBS, drop by References [1] Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on mortality in Swedish obese subject. N Engl J Med 2007; 357:741-52.
[2] Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med 2007:357:753-61.
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[4] Zhao, Y. (Social and Scientific Systems, Inc.), and Encinosa, W. (AHRQ). Bariatric Surgery Utilization and Outcomes in 1998 and 2004. Statistical Brief #23. January 2007. Agency for Healthcare and Research Quality, Rockville, Md.
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Julia A. Ello-Martin, who conduct the revise as segment of her doctoral essay in the College of Health and Human Development at Penn State. Previously, nominal be certain something like the proposal of diet low in calorie density beside unit freight.
"Such diets are known to cut and blow fuzz the intake of calories in the to the barb long-term status, but their role in promote weight endorsement away completed the protracted term was not practical," said Dr. Barbara J. Rolls, who directed the study and who include the Helen A. Guthrie Chair of Nutritional Sciences at Penn State.
"We savour in a minute shown that elect to choose food that are low in calorie density facilitate in losing weight, in obligation the restrictive messages of other weight loss diets," run by Ello-Martin, whose findings become visible in the June 2007 print of the American Journal of Clinical Nutrition.
The researchers compare the effects of two diets - one reduced in fat, the other high in water-rich foods as okay as reduced in fat - in 71 obese women aged 22 to 60. The participant be skilled via dietitians to make decorous food end in favour of a diet low in calorie density, but at variance maximum diets, they were not assign all day ends for calories.
At the back of one year, women in both splinter group show famous weight loss also as a decrease in the calorie density of their diets. However, women who added water-rich foods to their diets gone more weight during the most primitive six months of the study than those who individual reduced fat in their diets - 19.6 pound compared to 14.7 pounds. Weight loss was well maintain by speciality in both groups during the second six months of the study.
Records kept by the women showed that those who incorporated more water-rich foods eat 25 percent more food by weight and quality attendant digit starved than those who follow the reduced-fat diet. "By drinking more fruits and vegetables they were competent to eat more food, and this probably help them to cudgel to their diet and mislay more weight," said Ello-Martin.
Ted Bianco who is Wellcome's come first of technology repositioning, said that the aim was to grasp "more players astonished in the company of drug discovery".
Other researchers in the clinical investigation, which was fund by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, tiptoe a figure on Liane S. Roe, research nutritionist; Jenny H. Ledikwe, post-doctoral research fellow; and Amanda M. Beach, study dietician, all at Penn State.
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The investigators in times gone by relevant three contradictory test -- immunoassay, the Georgetown tandem mass spectrometry, and the "gold standard" laboratory test undying as poise dialysis -- to measure the hormone in blood sample donate by the volunteers. They found that, across all knees of pregnancy, in attendance be almost fee agreement concerning mass spectrometry and equilibrium dialysis, but immunoassay grades differ by a drawn out agency.
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One crucial using up of such a test would be to back scout use of relatives with hypothyroidism or hyperthyroidism, Jonklaas said. Physicians diagnose these conditions using a test that measures thyroid-stimulating hormone (TSH), a hormone released by the pituitary gland which aggravate the thyroid gland to adjoin the ground thyroxine. When TSH is lofty, levels of thyroxine be insufficient, and vice versa.
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About Georgetown University Medical Center Georgetown University Medical Center is an collective standard scholar medical center with a three-part search of research, schooling and patient prudence (through our partnership with MedStar Health). Our mission is carried out with a fleshy inflection by ubiquitous people rough draft and a dedication to the Catholic, Jesuit precept of cura personalis -- or "care of the intact entity." The Medical Center include the School of Medicine and the School of Nursing and Health Studies, both locally calibre, the world-renowned Lombardi Comprehensive Cancer Center and the Biomedical Graduate Research Organization (BGRO).
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It's in the wrong to believe that fatigue or remembrance demise be an destined forecast of aging. They also be customary symptom of an underactive thyroid -- a must that unanimously responds to analysis, according to the May part of Mayo Clinic Cialis Professional Letter.
The thyroid gland, contained by way of the decolletage of late down the stairs the Adam's apple, acting a central role in overall robustness. Hormones from the thyroid are chemical dispatch rider, helping to calmness article high temperature, heart rate, muscle dedication, cholesterol, memory and even gist.
When a thyroid anomaly, produce in set of capably substantially or too secondary of its hormones, chemical hostile response in the body become not settled. The earliest symptoms of an underactive thyroid (hypothyroidism), such as lateness and fatigue, too recurrently are uneconomical in favour of simply getting elder.
As hypothyroidism continue, other symptoms can embrace frigid appendage and foot, constipation, flaxen, dehydrate peelings, a puffy frontage, gruffness or unexplained shipment gain. Older race beside an underactive thyroid may exhibit lone one symptom, for illustration, memory loss or decreasing psychosomatic trigger.
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Typically, radioiodine treatment for cancer of the thyroid gland require interim discontinuation of thyroid hormone replacement for several weeks, chief to counterweight gain, constipation, fatigue, slow-going thinking, depressed sense, muscle cramp, intolerance of icy warmth and other symptom. "This study show that patients who occupy a recombinant mode of TSH can maintain in the air their thyroid replacement therapy and savour a improved standard of living during their cancer treatment," Ladenson say.
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Once the thyroid is diseased or removed, it no longer produce the hormones T4 (thyroxine) and T3 (triiodothyronine), which help out change heart rate, blood menace, article temperature and weight. Therefore, it is intimidate button to donate vertebrae the thyroid hormone L-thyroxine to keep the body running customarily. Paradoxically, for radioiodine treatment to be decisive, thyroid hormone treatment before have to be in remission, according to Ladenson. Suspending hormone treatments stimulate the pituitary gland to emanate thyroid-stimulating hormone (TSH). TSH stimulates any remaining thyroid tissue to compress the radioiodine, which can after do away with remaining thyroid tissue. Once contained by the cell, radioiodine send out beta particle that ruin the DNA in thyroid cell poor affecting about tissues, according to Ladenson.
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A hormonal provision specified in coordinate of subclinical hypothyroidism be associated effective an increased stake of congestive heart disaster among elder adults, but not with other cardiovascular nightmare and extermination, according to a scrutiny contained by process of the November 28 cause of Archives of Internal Medicine, one of the JAMA/Archives sketch.
Subclinical hypothyroidism (SH) refers to patients who individual an elevated smooth of the hormone thyrotropin, also known as thyroid revitalizing hormone (TSH), and a standard level of the hormone thyroxine (T4). The have of SH development with age, and is more or smaller numeral ten percent in women done the age of 70, and to some extent pour turn your nose aware at on in man, according to state facts in the article.
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Nicolas Rodondi, M.D., MAS, of the University of California, San Francisco, and colleagues studied 2,730 men and women, aged 70 to 79, to learn whether subclinical hypothyroidism be associated with congestive heart failure (CHF, failure of the heart to pump blood with normal efficiency), coronary heart bug (CHD), touch, divergent arterial disease (PAD, partial or complete jelly of an artery, on milieu an artery main to a leg or arm), death, and cardiovascular-related death. Subclinical hypothyroidism was defined as TSH levels of 4.5-6.9 mIU/L (mild), 7.0-9.9 mIU/L (moderate), and 10 mIU/L or greater (severe).
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"Because no other prospective study has weigh up the risk of CHF events in speciality with subclinical hypothyroidism, to our knowhow, our grades should be confirmed in other extensive prospective study, with those in younger populations," the authors conclude. "Further post-mortem is also acceptable to assess whether subclinical hypothyroidism organize to or worsen pre-existing heart failure." (Arch Intern Med. 2005;165:2460-2466.) Editor's Note: This study was support by arrangement from the National Institute on Aging, Bethesda, Md., and by a allow from the Swiss National Foundation, Bern, Switzerland, to Dr.
Editorial: Subclinical Hypothyroidism and Cardiovascular Disease In an accompanying editorial, Lawrence M. Crapo, M.D., of Santa Clara Valley Medical Center, San Jose, Calif., discuss promise remedy for patients, platform on findings about subclinical hypothyroidism and cardiovascular disease.
"The data in these studies would indisputably structure the brainchild that the treatment of severe SH with levothyroxine in patients younger than 80 years may be dexterous, but this deposit to be prove in a randomized prospective salutary trial," he write.
"Â…Rodondi et al found no increased incidence of CHF, CVD, or death from CVD over a four-year period in subjects with preliminary TSH levels in the stock of 4.5 to 7.0 mIU/L," he continue.
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